Actinic Keratoses (AKs) are rough scaly spots which appear on the sun-damaged
skin. They are especially common in fair-skinned persons and are caused by
repeated sun exposures over many years. Sun-damaged skin is dry and wrinkled
and may form persistently scaly spots: actinic (solar) keratosis. For an overview please see DermNet.NZ In our opinion, AKs are routinely and systematically overtreated in the U.S.
AKs = Cash Cow
The standard treatment of a AKs calls for removal of the defective skin
cells with liquid nitrogen, topical fluorouracil or imiquimod. New skin then
forms from deeper cells which have escaped sun damage. However, there is no
evidence that treatment of most AKs is of any value. Removal of all AKs is
quick and easy and very lucrative for practicing physicians in some countries.
While textbooks of dermatology state that around 10% of AKs progress to skin
cancer (squamous cell carcinoma, SCC) if left untreated, this number was
derived from no study and crept into the literature without factual basis. The
only decent study on the malignant transformation of AKs was performed in
Australia by Professor Robin Marks, a research dermatologist.
This is an abstract of Robin Marks' study:
Br J Dermatol 1986 Dec;115(6):649-655
Spontaneous remission of solar keratoses: the case for conservative management.
Marks R, Foley P, Goodman G, Hage BH, Selwood TS
One thousand and forty people aged 40 years and over, 616 (59.2%) of whom
had solar keratoses, were followed for 12 months. Two hundred and twenty-four
people (36.4%) had a spontaneous remission of at least one of their solar
keratoses. A total of 485 lesions (25.9%) underwent spontaneous remission out
of the 1873 lesions that were present at the first examination of these
224 people. There was no significant difference between the number of lesions
present at the initial examination in those who had a spontaneous remission
compared with those who did not. There was a 21.8% increase in the total
number of solar keratoses in the 1040 people studied in the 12-month period,
due to new lesions forming at the same time as remissions were occurring. The
incidence rate of squamous cell carcinoma occurring in the people with solar keratoses
was 0.24% for each solar keratosis present at the original examination. With a
substantial proportion of solar keratoses remitting spontaneously, plus the low
rate of malignant transformation and the low potential for metastasis to occur
from squamous cell carcinoma arising in a solar keratosis, the rationale of
treating all solar keratoses appears questionable.
Comment: Robin Marks
could not get his study published in the United States or Australia. The reason
was that dermatologists derive a significant proportion of their income from
these usually banal lesions. The image of the dermatologist running from room
to room with a spray bottle of liquid nitrogen is all too familiar to elderly
patients in the United States.
There are lesions which look like AKs which need treatment. These are the
hypertrophic AKs which can be indistinguishable from early squamous cell
carcinomas. An experienced dermatologist will be able to tell the banal from
the worrisome in most cases. However, it will be a long time before the average
practitioner will give up income for the pursuit of truth - so it is caveat
emptor.
A retired physician we know saw a dermatologist for routine care. The
latter froze ~ 15 lesions with liquid nitrogen and the bill to Medicare was
> $1000 for the ten minute office visit. The retired doctor wrote to
the dermatologist and said if this wasn't fixed he would be reported for
fraud. Was it? You be the judge.
The take-home message is that most
actinic keratoses are innocuous. They can simply be observed. A
small subset will progress to squamous cell cancer -- but these behave and look
different. What is important is that AKs are markers for persons at risk
to develop skin cancers (squamous cell, basal cell and melanoma) and these individuals
need to perform regular self-skin exams and visit a dermatologist
periodically. There will be dermatologists who disagree with this.
However, this handout is our opinion based on years of practice and a study of
the pertinent literature.
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