This is a new product for actinic (solar} keratoses that may be better tolerated than 5% % fluorouracil cream and more effective than Solareze (topical diclofenac).
It is indicated for "topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent patients.
Not available in the U.S. yet, but there are probably ways to obtain it.
Product Details from the Web:
| Drug Name:
| ACTIKERALL |
|---|---|
| Legal Class:
|
POM |
| Drug Class: | Actinic keratoses treatments |
| How Supplied: | Fluorouracil 0.5%, salicylic acid 10% |
| Price:
|
Soln, 25ml=£38.30. |
| Indications:
|
Topical treatment of slightly palpable and/or moderately thick hyperkeratotic actinic keratosis (grade I/II) in immunocompetent patients. |
| Adults:
|
Apply to lesion once daily for up to 12 weeks. Leave to dry to a film, do not cover; peel off film before reapplying. Max area to be treated at any one time, 25cm2. Optimal effect, up to 8 weeks after treatment. |
| Children:
|
Not recommended. |
| General Warnings for Fluorouracil + salicylic acid | |
|---|---|
| Contraindications:
|
Renal impairment. Pregnancy, lactation. |
| Precautions:
|
Avoid contact with eyes and mucous membranes. Sensory disturbances (eg, diabetes). Areas with thin epidermis; apply less frequently and monitor closely. May stain textiles or acrylics. |
| Interactions:
|
Phenytoin, methotrexate, sulfonylureas. |
| Side Effects:
|
Local reactions, skin exfoliation, headache. |