Topical (5-fluorouracil [5-FU]) as a 5% solution was used to treat isolated actinic keratoses of the lips as well as diffuse actinic damage of the lower lip. Although producing considerable temporary discomfort, final results proved excellent, with recurrences in only two of 12 patients treated. Preliminary biopsy of suspicious infiltrated areas is mandatory, as is careful follow-up to ensure complete healing. Topical fluorouracil is an alternative to surgical excision of the vermilion border of the lip in those patients with severe diffuse actinic damage of the lips.
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