Efficacy of Oral Itraconazole in the Treatment and Relapse Prevention of Moderate to Severe Seborrheic Dermatitis: A Randomized, Placebo-Controlled Trial.
Ghodsi SZ, Abbas Z, Abedeni R. Am J Clin Dermatol. 2015 Oct;16(5):431-
Abstract
BACKGROUND: Seborrheic dermatitis (SD) is a chronic and relapsing disease and topical therapy may be associated with failure, particularly in severe disease. Itraconazole has been suggested as an effective treatment for severe SD. Previous studies have been open clinical trials with variable results.
OBJECTIVE: The aim of this study was to determine the efficacy of oral itraconazole in the treatment of patients with moderate to severe SD.
CONCLUSION: Itraconazole is not only an effective and safe therapy for controlling exacerbations of SD but may also be used as maintenance therapy to prevent disease recurrence.
Discussion in NEJM Journal Watch. If you can'topen link:
Download Seb Derm Itraconazole Journal Watch